2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P2169
    Small cardioactive peptide A 98035-79-1 98%
    Small cardioactive peptide A (SCPA) is a neuropeptide that can be obtained from Aplysia.
    Small cardioactive peptide A
  • HY-P2183
    PEN(mouse) 1236955-25-1 98%
    PEN(mouse) (proSAAS(221-242)) is the precursor of a number of peptides that function as neuropeptides.
    PEN(mouse)
  • HY-P2283
    β-Amyloid (1-37) (human) 186359-67-1 98%
    β-Amyloid (1-37) (human) correlates moderately with Mini-Mental State Examination (MMSE) scores in Alzheimer disease. β-Amyloid (1-37) (human) possesses an added diagnostic value.
    β-Amyloid (1-37) (human)
  • HY-P2285
    AC 253 151804-79-4 98%
    AC 253, an amylin antagonist, inhibits 125I-adrenomedullin binding, with an IC50 of 25 nM.
    AC 253
  • HY-P2298
    TAT-P4-(DATC5)2 98%
    TAT-P4-(DATC5)2 is a high-affinity peptide inhibitor of the PICK1 (protein interacting with C kinase-1) PDZ domain, with a Ki of 1.7 nM. TAT-P4-(DATC5)2 can inhibit addiction in rats.
    TAT-P4-(DATC5)2
  • HY-P2325
    Exoenzyme C3, clostridium botulinum 58319-92-9
    Exoenzyme C3, clostridium botulinum is a promising agent to inactivate RhoA in neurons due to preventing the detrimental effect of active Rho in the recovery of injured neuronal systems. Exoenzyme C3, clostridium botulinum is used for the study of post-traumatic neuro-regeneration.
    Exoenzyme C3, clostridium botulinum
  • HY-P2342
    Angiopep-Bim BH3 hydrochloride 98%
    Angiopep-Bim BH3 hydrochloride, a BBB penetrated peptode, could be used to investigate the permeability of CNS therapeutics.
    Angiopep-Bim BH3 hydrochloride
  • HY-P2374
    Ac-DMQD-CHO 259199-63-8 98%
    Ac-DMQD-CHO is a selective inhibitor for caspase 3, with IC50 of 39 nM. Ac-DMQD-CHO reduces apoptosis, and exhibits neuroprotective efficacy.
    Ac-DMQD-CHO
  • HY-P2434
    AP102 846569-60-6 98%
    AP102 is a dual SSTR2/SSTR5-specific somatostatin analog (SSA). AP102 is a disulfide-bridged octapeptide SSA containing synthetic iodinated amino acids. AP102 binds with subnanomolar affinity to SSTR2 and SSTR5 (IC50: 0.63 and 0.65 nM, respectively). AP102 does not bind to SSTR1 or SSTR3. AP102 can be used for acromegaly and neuroendocrine tumors research.
    AP102
  • HY-P2475
    [Pro9]-Substance P 104486-69-3 98%
    [Pro9]-Substance P is a potent, reversible and selective agonist of NK-1 tachykinin receptors with an EC50 of 0.93 nM.
    [Pro9]-Substance P
  • HY-P2550
    β-Amyloid (1-40), FAM-labeled 1678416-08-4 98%
    β-Amyloid (1-40), FAM-labeled is a FAM fluorescently-labelled β-Amyloid (1-40) peptide (λex= 492 nm and λem= 518 nm).
    β-Amyloid (1-40), FAM-labeled
  • HY-P2562
    β-Amyloid (1-38), mouse, rat 186359-66-0 98%
    β-Amyloid (1-38), mouse, rat is composed of 38 aa (1-38 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer’s disease.
    β-Amyloid (1-38), mouse, rat
  • HY-P2572
    Deltakephalin 85286-38-0 98%
    Deltakephalin is a potent, selective opiate δ-receptor agonist. Deltakephalin has analgesic properties.
    Deltakephalin
  • HY-P2579
    Dafphedyn 111846-43-6 98%
    Dafphedyn is an analogue of Dynorphin (1-13). Dafphedyn has diuretic and profound analgesia effects that can be antagonized by centrally administered Naltrexone (HY-76711) or Naloxone (HY-17417A).
    Dafphedyn
  • HY-P2626
    [D-Ala2]-Met-Enkephalin 61370-87-4 98%
    [D-Ala2]-Met-Enkephalin, an opioid peptide, is a potent opioid agonist. [D-Ala2]-Met-Enkephalin inhibits ACh-induced and suckling-induced oxytocin (OT) release.
    [D-Ala2]-Met-Enkephalin
  • HY-P2632
    RAD16-I 289042-25-7 98%
    RAD16-I, a soft nanofibrous self-assembling peptide, is a suitable microenvironment for human mesenchymal stem cells’ (hMSC) proliferation and differentiation into chondrocytes. RAD16-I is a well-studied ionic complementary peptide was used as a model to check potential amyloid-like staining properties of SAPNFs.
    RAD16-I
  • HY-P2669
    Boc-YPGFL(O-tBu) 179124-36-8 98%
    Boc-YPGFL(O-tBu) is a selective δ opioid receptor (DOR) peptide antagonist.
    Boc-YPGFL(O-tBu)
  • HY-P2699
    ω-Grammotoxin SIA 152617-90-8 98%
    ω-Grammotoxin SIA (GrTx) is P/Q and N-type voltage-gated Calcium channels inhibitor. ω-Grammotoxin SIA is also a protein toxin that can be obtained from spider venom. ω-Grammotoxin SIA has the potential to study neurological diseases as well as cardiovascular diseases.
    ω-Grammotoxin SIA
  • HY-P2710
    Noxiustoxin 85205-49-8 98%
    Noxiustoxin is a toxin from the venom of the Mexican scorpion Centruroides noxius which block voltage-dependent potassium channel (Kv1.3, IC50 = 360 nM), and calcium-activated potassium channel. Noxiustoxin plays an important role in neuroinflammatory disease.
    Noxiustoxin
  • HY-P2712
    Chemerin-9, mouse 686324-96-9 98%
    Chemerin-9, mouse (Chemerin148-156, mouse) is a C-terminal nonapeptide of chemerin. Chemerin-9, mouse is a ligand for ChemR23 (EC50 = 42 nM). Chemerin-9, mouse reduces basal lipolysis in primary mouse white adipocytes(IC50 = 3.3 nM). Chemerin-9, mouse enhances memory and relieves Aβ1-42-induced memory impairment in AD mice. Chemerin-9, mouse also inhibits atherogenesis.
    Chemerin-9, mouse
Cat. No. Product Name / Synonyms Application Reactivity